RIC8 (RIC8A) (NM_021932) Human Recombinant Protein
Product Specifications
Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex (By similarity) . Also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.[UniProtKB/Swiss-Prot Function]
Synonyms
RIC8
Gene ID
60626
UniProt
Q9NPQ8
Accession Number mRNA
NM_021932
Chromosomal Location
11p15.5
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
60.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RIC8A
Species
Human
Protein ID
NP_068751
Overview
Recombinant protein of human resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) (RIC8A)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/60626
Uniprot URL
https://www.uniprot.org/uniprot/Q9NPQ8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021932
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_068751
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