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HNF 4 alpha (HNF4A) (NM_001030003) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Synonyms

FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF-14; TCF14

Gene ID

3172

UniProt

P41235

Accession Number mRNA

NM_001030003

Chromosomal Location

20q13.12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Maturity onset diabetes of the young

Field of Research

Maturity onset diabetes of the young

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, ES Cell Differentiation/IPS, Nuclear Hormone Receptor, Transcription Factors

Molecular Weight

48.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HNF4A

Species

Human

Protein ID

NP_001025174

Overview

Recombinant protein of human hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 5

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3172

Uniprot URL

https://www.uniprot.org/uniprot/P41235

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001030003

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001025174

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