BTK (NM_000061) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

Overview

Recombinant protein of human Bruton agammaglobulinemia tyrosine kinase (BTK)

Synonyms

AGMX1; AT; ATK; BPK; IGHD3; IMD1; PSCTK1; XLA

Gene ID

695

UniProt

Q06187, Q5JY90

Accession Number mRNA

NM_000061

Chromosomal Location

Xq22.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency

Field of Research

B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

76.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

BTK

Species

Human

Protein ID

NP_000052

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/695

Uniprot URL

https://www.uniprot.org/uniprot/Q06187

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000061

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000052

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