HES1 (NM_005524) Human Recombinant Protein
Product Specifications
Background
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human hairy and enhancer of split 1, (Drosophila) (HES1)
Synonyms
BHLHb39; HES-1; HHL; HRY
Gene ID
3280
UniProt
Q14469
Accession Number mRNA
NM_005524
Chromosomal Location
3q29
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Maturity onset diabetes of the young, Notch signaling pathway
Field of Research
Maturity onset diabetes of the young, Notch signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors
Molecular Weight
29.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HES1
Species
Human
Protein ID
NP_005515
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3280
Uniprot URL
https://www.uniprot.org/uniprot/Q14469
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005524
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005515
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