MARCH8 (NM_001002265) Human Recombinant Protein

Product Specifications

Background

MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19) . MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]) .[supplied by OMIM, Apr 2010]

Overview

Recombinant protein of human membrane-associated ring finger (C3HC4) 8 (MARCH8), transcript variant 6

Synonyms

C-MIR; MARCH-VIII; MIR; RNF178

Gene ID

220972

UniProt

Q5T0T0

Accession Number mRNA

NM_001002265

Chromosomal Location

10q11.21-q11.22

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

32.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.