MARCH8 (NM_001002265) Human Recombinant Protein
Product Specifications
Background
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19) . MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]) .[supplied by OMIM, Apr 2010]
Synonyms
C-MIR; MARCH-VIII; MIR; RNF178
Gene ID
220972
UniProt
Q5T0T0
Accession Number mRNA
NM_001002265
Chromosomal Location
10q11.21-q11.22
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
32.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
44628
Species
Human
Protein ID
NP_001002265
Overview
Recombinant protein of human membrane-associated ring finger (C3HC4) 8 (MARCH8), transcript variant 6
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/220972
Uniprot URL
https://www.uniprot.org/uniprot/Q5T0T0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001002265
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001002265
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