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HSD11B1 (NM_181755) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) ) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

Synonyms

11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1

Gene ID

3290

UniProt

P28845, X5D2L1

Accession Number mRNA

NM_181755

Chromosomal Location

1q32.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

Field of Research

Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

29674492

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

32.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HSD11B1

Species

Human

Protein ID

NP_861420

Overview

Recombinant protein of human hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 2

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3290

Uniprot URL

https://www.uniprot.org/uniprot/P28845

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_181755

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_861420

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