PPAR gamma (PPARG) (NM_015869) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human peroxisome proliferator-activated receptor gamma (PPARG), transcript variant 2

Synonyms

CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma

Gene ID

5468

UniProt

P37231

Accession Number mRNA

NM_015869

Chromosomal Location

3p25.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer

Field of Research

Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Molecular Weight

57.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.