MSK2 / RSK-B (RPS6KA4) (NM_003942) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Overview
Recombinant protein of human ribosomal protein S6 kinase, 90kDa, polypeptide 4 (RPS6KA4), transcript variant 1
Synonyms
MSK2; RSK-B; S6K-alpha-4
Gene ID
8986
UniProt
O75676, A0PJF8
Accession Number mRNA
NM_003942
Chromosomal Location
11q13.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
MAPK signaling pathway, Neurotrophin signaling pathway
Field of Research
MAPK signaling pathway, Neurotrophin signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Transcription Factors
Molecular Weight
85.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RPS6KA4
Species
Human
Protein ID
NP_003933
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8986
Uniprot URL
https://www.uniprot.org/uniprot/O75676
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003942
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003933
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