DNMT3A (NM_022552) Human Recombinant Protein
Product Specifications
Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Synonyms
DNMT3A2; HESJAS; M.HsaIIIA; TBRS
Gene ID
1788
UniProt
Q9Y6K1
Accession Number mRNA
NM_022552
Chromosomal Location
2p23.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cysteine and methionine metabolism, Metabolic pathways
Field of Research
Cysteine and methionine metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
27468168
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
101.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DNMT3A
Species
Human
Protein ID
NP_072046
Overview
Recombinant protein of human DNA (cytosine-5-) -methyltransferase 3 alpha (DNMT3A), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1788
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y6K1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022552
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_072046
Curated Selection
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