DNMT3A (NM_022552) Human Recombinant Protein

Product Specifications

Background

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]

Overview

Recombinant protein of human DNA (cytosine-5-) -methyltransferase 3 alpha (DNMT3A), transcript variant 3

Synonyms

DNMT3A2; HESJAS; M.HsaIIIA; TBRS

Gene ID

1788

UniProt

Q9Y6K1

Accession Number mRNA

NM_022552

Chromosomal Location

2p23.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cysteine and methionine metabolism, Metabolic pathways

Field of Research

Cysteine and methionine metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

27468168

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

101.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.