CTNS (NM_004937) Human Recombinant Protein

Product Specifications

Background

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

Overview

Purified recombinant protein of Homo sapiens cystinosis, nephropathic (CTNS), transcript variant 2

Synonyms

CTNS-LSB; PQLC4; SLC66A4

Gene ID

1497

UniProt

O60931, A0A0S2Z3K3

Accession Number mRNA

NM_004937

Chromosomal Location

17p13.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Lysosome

Field of Research

Lysosome

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

41.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.