CTNS (NM_004937) Human Recombinant Protein
Product Specifications
Background
This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Synonyms
CTNS-LSB; PQLC4; SLC66A4
Gene ID
1497
UniProt
O60931, A0A0S2Z3K3
Accession Number mRNA
NM_004937
Chromosomal Location
17p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysosome
Field of Research
Lysosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
41.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CTNS
Species
Human
Protein ID
NP_004928
Overview
Purified recombinant protein of Homo sapiens cystinosis, nephropathic (CTNS), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1497
Uniprot URL
https://www.uniprot.org/uniprot/O60931
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004937
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004928
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