Tau (MAPT) (NM_005910) Human Recombinant Protein
Product Specifications
Background
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human microtubule-associated protein tau (MAPT), transcript variant 2
Synonyms
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; tau-40
Gene ID
4137
UniProt
P10636, A0A024RA17
Accession Number mRNA
NM_005910
Chromosomal Location
17q21.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, MAPK signaling pathway
Field of Research
Alzheimer's disease, MAPK signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
45.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MAPT
Species
Human
Protein ID
NP_005901
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4137
Uniprot URL
https://www.uniprot.org/uniprot/P10636
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005910
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005901
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