TrkC (NTRK3) (NM_002530) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Overview
Recombinant protein of human neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 2
Synonyms
Gp145 (trkC) ; GP145-TrkC; TRKC
Gene ID
4916
UniProt
Q16288, X5D7M5
Accession Number mRNA
NM_002530
Chromosomal Location
15q25.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Neurotrophin signaling pathway
Field of Research
Neurotrophin signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Transmembrane
Molecular Weight
89.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NTRK3
Species
Human
Protein ID
NP_002521
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4916
Uniprot URL
https://www.uniprot.org/uniprot/Q16288
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002530
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002521
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