GJA8 (NM_005267) Human Recombinant Protein
Product Specifications
Background
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome. [provided by RefSeq, Dec 2009]
Overview
Recombinant protein of human gap junction protein, alpha 8, 50kDa (GJA8)
Synonyms
CAE; CAE1; CTRCT1; CX50; CZP1; MP70
Gene ID
2703
UniProt
P48165, X5D7G1
Accession Number mRNA
NM_005267
Chromosomal Location
1q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Ion Channels: Other, Transmembrane
Molecular Weight
48 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GJA8
Species
Human
Protein ID
NP_005258
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2703
Uniprot URL
https://www.uniprot.org/uniprot/P48165
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005267
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005258
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