GLUT4 (SLC2A4) (NM_001042) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM) . [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4)

Synonyms

GLUT4

Gene ID

6517

UniProt

P14672

Accession Number mRNA

NM_001042

Chromosomal Location

17p13.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Adipocytokine signaling pathway, Insulin signaling pathway, Type II diabetes mellitus

Field of Research

Adipocytokine signaling pathway, Insulin signaling pathway, Type II diabetes mellitus

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

54.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.