GRAF (ARHGAP26) (NM_015071) Human Recombinant Protein
Product Specifications
Background
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Synonyms
GRAF; GRAF1; OPHN1L; OPHN1L1
Gene ID
23092
UniProt
Q9UNA1
Accession Number mRNA
NM_015071
Chromosomal Location
5q31.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
92.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ARHGAP26
Species
Human
Protein ID
NP_055886
Overview
Recombinant protein of human Rho GTPase activating protein 26 (ARHGAP26), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23092
Uniprot URL
https://www.uniprot.org/uniprot/Q9UNA1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015071
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055886
Curated Selection
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