PIK3AP1 (NM_152309) Human Recombinant Protein

Product Specifications

Background

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K) -Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1)

Synonyms

BCAP

Gene ID

118788

UniProt

Q6ZUJ8, Q86YV3

Accession Number mRNA

NM_152309

Chromosomal Location

10q24.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

B cell receptor signaling pathway

Field of Research

B cell receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

90.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.