PIK3AP1 (NM_152309) Human Recombinant Protein
Product Specifications
Background
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K) -Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.[UniProtKB/Swiss-Prot Function]
Synonyms
BCAP
Gene ID
118788
UniProt
Q6ZUJ8, Q86YV3
Accession Number mRNA
NM_152309
Chromosomal Location
10q24.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
B cell receptor signaling pathway
Field of Research
B cell receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
90.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PIK3AP1
Species
Human
Protein ID
NP_689522
Overview
Recombinant protein of human phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/118788
Uniprot URL
https://www.uniprot.org/uniprot/Q6ZUJ8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_152309
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_689522
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