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LSS (NM_001001438) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene catalyzes the conversion of (S) -2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]

Overview

Recombinant protein of human lanosterol synthase (2, 3-oxidosqualene-lanosterol cyclase) (LSS), transcript variant 2

Synonyms

APMR4; CTRCT44; HYPT14; OSC

Gene ID

4047

UniProt

P48449, B2R694

Accession Number mRNA

NM_001001438

Chromosomal Location

21q22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Steroid biosynthesis

Field of Research

Metabolic pathways, Steroid biosynthesis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

83.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

LSS

Species

Human

Protein ID

NP_001001438

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4047

Uniprot URL

https://www.uniprot.org/uniprot/P48449

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001001438

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001001438

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