UBA6 (NM_018227) Human Recombinant Protein

Product Specifications

Background

Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3) . UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]) .[supplied by OMIM, Mar 2008]

Overview

Recombinant protein of human ubiquitin-like modifier activating enzyme 6 (UBA6)

Synonyms

E1-L2; MOP-4; UBE1L2

Gene ID

55236

UniProt

A0AVT1, A1LT96

Accession Number mRNA

NM_018227

Chromosomal Location

4q13.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Ubiquitin mediated proteolysis

Field of Research

Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

117.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.