SETD3 (NM_032233) Human Recombinant Protein

Product Specifications

Background

Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395) . Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964) . Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human SET domain containing 3 (SETD3), transcript variant 1

Synonyms

C14orf154; hSETD3

Gene ID

84193

UniProt

Q86TU7, A0A024R6K3

Accession Number mRNA

NM_032233

Chromosomal Location

14q32.2

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

67.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.