CD247 (NM_198053) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human CD247 molecule (CD247), transcript variant 1
Synonyms
CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ
Gene ID
919
UniProt
P20963
Accession Number mRNA
NM_198053
Chromosomal Location
1q24.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
Field of Research
Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
16.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CD247
Species
Human
Protein ID
NP_932170
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/919
Uniprot URL
https://www.uniprot.org/uniprot/P20963
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_198053
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_932170
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