PCCA (NM_000282) Human Recombinant Protein
Selected Variant
PH36051M5
Size: 20 µg
Product Specifications
Background
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Overview
Recombinant protein of human propionyl Coenzyme A carboxylase, alpha polypeptide (PCCA), nuclear gene encoding mitochondrial protein, transcript variant 1
Synonyms
PCCase alpha subunit; propanoyl-CoA:carbon dioxide ligase alpha subunit; propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-coenzyme A carboxylase, alpha polypeptide; Propionyl Coenzyme A carboxylase alpha polypeptide
Gene ID
5095
UniProt
P05165
Accession Number mRNA
NM_000282
Chromosomal Location
13q32.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation
Field of Research
Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
75 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PCCA
Species
Human
Protein ID
NP_000273
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5095
Uniprot URL
https://www.uniprot.org/uniprot/P05165
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000282
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000273
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