Gelsolin (GSN) (NM_000177) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF) . Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human gelsolin (amyloidosis, Finnish type) (GSN), transcript variant 1

Synonyms

ADF; AGEL

Gene ID

2934

UniProt

P06396, A0A384MEF1

Accession Number mRNA

NM_000177

Chromosomal Location

9q33.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton

Field of Research

Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Secreted Protein

Molecular Weight

82.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.