IGF1 Receptor (IGF1R) (NM_000875) Human Recombinant Protein
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Synonyms
CD221; IGFIR; IGFR; JTK13
Gene ID
3480
UniProt
P08069
Accession Number mRNA
NM_000875
Chromosomal Location
15q26.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
Field of Research
Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Transmembrane
Molecular Weight
81 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IGF1R
Species
Human
Protein ID
NP_000866
Overview
Recombinant protein of human insulin-like growth factor 1 receptor (IGF1R)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3480
Uniprot URL
https://www.uniprot.org/uniprot/P08069
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000875
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000866
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