PERK (EIF2AK3) (NM_004836) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Synonyms
PEK; PERK; WRS
Gene ID
9451
UniProt
Q9NZJ5, B3KY45
Accession Number mRNA
NM_004836
Chromosomal Location
2p11.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease
Field of Research
Alzheimer's disease
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
28416388
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane
Molecular Weight
122.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EIF2AK3
Species
Human
Protein ID
NP_004827
Overview
Recombinant protein of human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9451
Uniprot URL
https://www.uniprot.org/uniprot/Q9NZJ5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004836
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004827
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