PERK (EIF2AK3) (NM_004836) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

Overview

Recombinant protein of human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Synonyms

PEK; PERK; WRS

Gene ID

9451

UniProt

Q9NZJ5, B3KY45

Accession Number mRNA

NM_004836

Chromosomal Location

2p11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease

Field of Research

Alzheimer's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

28416388

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane

Molecular Weight

122.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.