UBE3C (NM_014671) Human Recombinant Protein
Product Specifications
Background
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human ubiquitin protein ligase E3C (UBE3C)
Synonyms
HECTH2
Gene ID
9690
UniProt
Q15386
Accession Number mRNA
NM_014671
Chromosomal Location
7q36.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
123.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
UBE3C
Species
Human
Protein ID
NP_055486
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9690
Uniprot URL
https://www.uniprot.org/uniprot/Q15386
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014671
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055486
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