EGLN1 (NM_022051) Human Recombinant Protein
Selected Variant
PH35972M5
Size: 20 µg
Product Specifications
Background
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3) . [provided by RefSeq, Nov 2009]
Overview
Recombinant protein of human egl nine homolog 1 (C. elegans) (EGLN1)
Synonyms
C1orf12; ECYT3; HALAH; HIF-PH2; HIFPH2; HPH-2; HPH2; PHD2; SM20; ZMYND6
Gene ID
54583
UniProt
Q9GZT9, R4SCQ0
Accession Number mRNA
NM_022051
Chromosomal Location
1q42.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Pathways in cancer, Renal cell carcinoma
Field of Research
Pathways in cancer, Renal cell carcinoma
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
45.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EGLN1
Species
Human
Protein ID
NP_071334
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/54583
Uniprot URL
https://www.uniprot.org/uniprot/Q9GZT9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022051
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071334
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