PAX3 (NM_181457) Human Recombinant Protein
Product Specifications
Background
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t (2;13) (q35; q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Homo sapiens paired box 3 (PAX3), transcript variant PAX3
Synonyms
CDHS; HUP2; WS1; WS3
Gene ID
5077
UniProt
P23760
Accession Number mRNA
NM_181457
Chromosomal Location
2q36.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transcription Factors
Molecular Weight
52.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PAX3
Species
Human
Protein ID
NP_852122
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5077
Uniprot URL
https://www.uniprot.org/uniprot/P23760
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_181457
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_852122
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