IL21 (NM_021803) Human Recombinant Protein
Selected Variant
PH35949M5
Size: 20 µg
Product Specifications
Background
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Overview
Recombinant protein of human interleukin 21 (IL21)
Synonyms
CVID11; IL-21; Za11
Gene ID
59067
UniProt
Q9HBE4, A0A224B028
Accession Number mRNA
NM_021803
Chromosomal Location
4q27
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Field of Research
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
18.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IL21
Species
Human
Protein ID
NP_068575
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/59067
Uniprot URL
https://www.uniprot.org/uniprot/Q9HBE4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021803
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_068575
Price
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