Pregnancy zone protein (PZP) (NM_002864) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
Synonyms
CPAMD6
Gene ID
5858
Accession Number mRNA
NM_002864
Chromosomal Location
12p13.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
163.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PZP
Species
Human
Protein ID
NP_002855
Overview
Recombinant protein of human pregnancy-zone protein (PZP)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5858
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002864
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002855
Curated Selection
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