C18orf1 (LDLRAD4) (NM_181483) Human Recombinant Protein
Product Specifications
Background
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.[UniProtKB/Swiss-Prot Function]
Synonyms
C18orf1
Gene ID
753
UniProt
O15165
Accession Number mRNA
NM_181483
Chromosomal Location
18p11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
25.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
LDLRAD4
Species
Human
Protein ID
NP_852148
Overview
Purified recombinant protein of Homo sapiens chromosome 18 open reading frame 1 (C18orf1), transcript variant b2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/753
Uniprot URL
https://www.uniprot.org/uniprot/O15165
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_181483
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_852148
Curated Selection
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