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HGF (NM_000601) Human Recombinant Protein

Selected Variant

PH35855M5

Size: 20 µg

Product Specifications

Background

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

Overview

Recombinant protein of human hepatocyte growth factor (hepapoietin A; scatter factor) (HGF), transcript variant 1

Synonyms

DFNB39; F-TCF; HGFB; HPTA; SF

Gene ID

3082

UniProt

P14210

Accession Number mRNA

NM_000601

Chromosomal Location

7q21.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cytokine-cytokine receptor interaction, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma

Field of Research

Cytokine-cytokine receptor interaction, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

26296757

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane

Molecular Weight

79.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HGF

Species

Human

Protein ID

NP_000592

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3082

Uniprot URL

https://www.uniprot.org/uniprot/P14210

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000601

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000592

Price

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