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FGF12 (NM_021032) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. [provided by RefSeq, Dec 2019]

Synonyms

DEE47; EIEE47; FGF12B; FHF1

Gene ID

2257

UniProt

P61328

Accession Number mRNA

NM_021032

Chromosomal Location

3q28-q29

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton

Field of Research

MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Secreted Protein

Molecular Weight

27.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FGF12

Species

Human

Protein ID

NP_066360

Overview

Recombinant protein of human fibroblast growth factor 12 (FGF12), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2257

Uniprot URL

https://www.uniprot.org/uniprot/P61328

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_021032

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_066360

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