Luteinizing Hormone beta (LHB) (NM_000894) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH) . Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human luteinizing hormone beta polypeptide (LHB)

Synonyms

CGB4; HH23; LSH-B; LSH-beta

Gene ID

3972

UniProt

P01229, A0A0F7RQE6

Accession Number mRNA

NM_000894

Chromosomal Location

19q13.33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

GnRH signaling pathway, Neuroactive ligand-receptor interaction

Field of Research

GnRH signaling pathway, Neuroactive ligand-receptor interaction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Secreted Protein

Molecular Weight

13.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.