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GRB 14 (GRB14) (NM_004490) Human Recombinant Protein

Product Specifications

Background

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Overview

Recombinant protein of human growth factor receptor-bound protein 14 (GRB14)

Synonyms

Growth factor receptor-bound protein 14

Gene ID

2888

UniProt

Q14449

Accession Number mRNA

NM_004490

Chromosomal Location

2q24.3

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

60.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

GRB14

Species

Human

Protein ID

NP_004481

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2888

Uniprot URL

https://www.uniprot.org/uniprot/Q14449

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004490

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004481

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