NALP1 (NLRP1) (NM_033004) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human NLR family, pyrin domain containing 1 (NLRP1), transcript variant 1
Synonyms
AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; JRRP; MSPC; NAC; NALP1; PP1044; SLEV1; VAMAS1
Gene ID
22861
UniProt
Q9C000
Accession Number mRNA
NM_033004
Chromosomal Location
17p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
NOD-like receptor signaling pathway
Field of Research
NOD-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
165.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NLRP1
Species
Human
Protein ID
NP_127497
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/22861
Uniprot URL
https://www.uniprot.org/uniprot/Q9C000
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_033004
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_127497
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