Prostaglandin D Synthase (PTGDS) (NM_000954) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2) . PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human prostaglandin D2 synthase 21kDa (brain) (PTGDS)

Synonyms

L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2

Gene ID

5730

UniProt

P41222, A0A024R8G3

Accession Number mRNA

NM_000954

Chromosomal Location

9q34.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Arachidonic acid metabolism, Metabolic pathways

Field of Research

Arachidonic acid metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

20.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.