Prostaglandin D Synthase (PTGDS) (NM_000954) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2) . PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
Synonyms
L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Gene ID
5730
UniProt
P41222, A0A024R8G3
Accession Number mRNA
NM_000954
Chromosomal Location
9q34.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Arachidonic acid metabolism, Metabolic pathways
Field of Research
Arachidonic acid metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
20.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PTGDS
Species
Human
Protein ID
NP_000945
Overview
Recombinant protein of human prostaglandin D2 synthase 21kDa (brain) (PTGDS)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5730
Uniprot URL
https://www.uniprot.org/uniprot/P41222
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000954
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000945
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