FAM83D (NM_030919) Human Recombinant Protein

Product Specifications

Background

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117) . May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692) . May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human family with sequence similarity 83, member D (FAM83D)

Synonyms

C20orf129; CHICA; dJ616B8.3

Gene ID

81610

UniProt

Q9H4H8

Accession Number mRNA

NM_030919

Chromosomal Location

20q11.23

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

67.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.