PAPSS1 (NM_005443) Human Recombinant Protein

Product Specifications

Background

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]) . SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005) .[supplied by OMIM, Mar 2008]

Overview

Recombinant protein of human 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)

Synonyms

ATPSK1; PAPSS; SK1

Gene ID

9061

UniProt

O43252

Accession Number mRNA

NM_005443

Chromosomal Location

4q25

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Purine metabolism, Selenoamino acid metabolism, Sulfur metabolism

Field of Research

Metabolic pathways, Purine metabolism, Selenoamino acid metabolism, Sulfur metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

70.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.