Glycophorin C (GYPC) (NM_016815) Human Recombinant Protein
Product Specifications
Background
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Synonyms
CD236; CD236R; GE; GE:GPC:GPD:GYPD; GPC; GPD; GYPD; PAS-2; PAS-2'
Gene ID
2995
UniProt
P04921
Accession Number mRNA
NM_016815
Chromosomal Location
2q14.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
11.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GYPC
Species
Human
Protein ID
NP_058131
Overview
Recombinant protein of human glycophorin C (Gerbich blood group) (GYPC), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2995
Uniprot URL
https://www.uniprot.org/uniprot/P04921
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016815
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_058131
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