Integrin alpha E (ITGAE) (NM_002208) Human Recombinant Protein
Product Specifications
Background
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Synonyms
CD103; HUMINAE
Gene ID
3682
UniProt
P38570
Accession Number mRNA
NM_002208
Chromosomal Location
17p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Regulation of actin cytoskeleton
Field of Research
Regulation of actin cytoskeleton
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Molecular Weight
128.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ITGAE
Species
Human
Protein ID
NP_002199
Overview
Recombinant protein of human integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) (ITGAE)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3682
Uniprot URL
https://www.uniprot.org/uniprot/P38570
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002208
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002199
Curated Selection
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