S6K1 (RPS6KB1) (NM_003161) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Synonyms
P70 S6KA; p70 (S6K) -alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A
Gene ID
6198
UniProt
P23443
Accession Number mRNA
NM_003161
Chromosomal Location
17q23.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Acute myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Insulin signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway
Field of Research
Acute myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Insulin signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
27801893
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
59 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RPS6KB1
Species
Human
Protein ID
NP_003152
Overview
Recombinant protein of human ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6198
Uniprot URL
https://www.uniprot.org/uniprot/P23443
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003161
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003152
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1075944-01 0.02 mg (E-Coli)
Recombinant Streptococcus thermophilus N utilization substance protein B homolog (nusB)
Ask
View Details MBS1075944-02 0.1 mg (E-Coli)
Recombinant Streptococcus thermophilus N utilization substance protein B homolog (nusB)
Ask
View Details MBS1075944-03 0.02 mg (Yeast)
Recombinant Streptococcus thermophilus N utilization substance protein B homolog (nusB)
Ask
View Details