BMAL1 (ARNTL) (NM_001030272) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Synonyms
BHLHe5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
Gene ID
406
UniProt
O00327, A0A140VKD3
Accession Number mRNA
NM_001030272
Chromosomal Location
11p15.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Circadian rhythm - mammal
Field of Research
Circadian rhythm - mammal
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
68.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ARNTL
Species
Human
Protein ID
NP_001025443
Overview
Recombinant protein of human aryl hydrocarbon receptor nuclear translocator-like (ARNTL), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/406
Uniprot URL
https://www.uniprot.org/uniprot/O00327
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001030272
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001025443
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