Gemin 5 (GEMIN5) (NM_015465) Human Recombinant Protein
Product Specifications
Background
This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Synonyms
GEMIN-5; NEDCAM
Gene ID
25929
UniProt
Q8TEQ6, Q58EZ8
Accession Number mRNA
NM_015465
Chromosomal Location
5q33.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
27507887
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
168.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GEMIN5
Species
Human
Protein ID
NP_056280
Overview
Recombinant protein of human gem (nuclear organelle) associated protein 5 (GEMIN5)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/25929
Uniprot URL
https://www.uniprot.org/uniprot/Q8TEQ6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015465
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_056280
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