RASGRP2 (NM_153819) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Overview
Recombinant protein of human RAS guanyl releasing protein 2 (calcium and DAG-regulated) (RASGRP2), transcript variant 2
Synonyms
CALDAG-GEFI; CDC25L
Gene ID
10235
UniProt
Q7LDG7
Accession Number mRNA
NM_153819
Chromosomal Location
11q13.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Chemokine signaling pathway, MAPK signaling pathway
Field of Research
Chemokine signaling pathway, MAPK signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
69.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RASGRP2
Species
Human
Protein ID
NP_722541
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10235
Uniprot URL
https://www.uniprot.org/uniprot/Q7LDG7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_153819
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_722541
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