DDX58 (NM_014314) Human Recombinant Protein
Product Specifications
Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD) . It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]
Overview
Recombinant protein of human DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58)
Synonyms
RIG-I; RIG1; RIGI; RLR-1; SGMRT2
Gene ID
23586
UniProt
O95786
Accession Number mRNA
NM_014314
Chromosomal Location
9p21.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway
Field of Research
Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
106.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DDX58
Species
Human
Protein ID
NP_055129
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23586
Uniprot URL
https://www.uniprot.org/uniprot/O95786
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014314
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055129
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