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TCF4 (NM_003199) Human Recombinant Protein

Product Specifications

Background

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

Overview

Recombinant protein of human transcription factor 4 (TCF4), transcript variant 2

Synonyms

BHLHb19; CDG2T; E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4

Gene ID

6925

UniProt

P15884, B3KVA4, A0A024R2C0

Accession Number mRNA

NM_003199

Chromosomal Location

18q21.2

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

Molecular Weight

71.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TCF4

Species

Human

Protein ID

NP_003190

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6925

Uniprot URL

https://www.uniprot.org/uniprot/P15884

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003199

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003190

Frequently Asked Questions

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