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MYBPC3 (NM_000256) Human Recombinant Protein

Selected Variant

PH35363M5

Size: 20 µg

Product Specifications

Background

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Homo sapiens myosin binding protein C, cardiac (MYBPC3)

Synonyms

CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C

Gene ID

4607

UniProt

Q14896, A5YM48

Accession Number mRNA

NM_000256

Chromosomal Location

11p11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Field of Research

Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

140.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MYBPC3

Species

Human

Protein ID

NP_000247

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4607

Uniprot URL

https://www.uniprot.org/uniprot/Q14896

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000256

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000247

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