ROCK2 (NM_004850) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Synonyms
ROCK-II
Gene ID
9475
UniProt
O75116, Q14DU5, A0A2P9DU05
Accession Number mRNA
NM_004850
Chromosomal Location
2p25.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Axon guidance, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, TGF-beta signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway
Field of Research
Axon guidance, Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, TGF-beta signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
160.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ROCK2
Species
Human
Protein ID
NP_004841
Overview
Recombinant protein of human Rho-associated, coiled-coil containing protein kinase 2 (ROCK2)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9475
Uniprot URL
https://www.uniprot.org/uniprot/O75116
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004850
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004841
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